| Grant ID | RR240079 |
| Awarded On | August 21, 2024 |
| Title | Recruitment of First-Time, Tenure-Track Faculty Members |
| Program | CPRIT Scholar |
| Award Mechanism | Recruitment of First-Time, Tenure-Track Faculty Members |
| Institution/Organization | The University of Texas M.D. Anderson Cancer Center |
| Principal Investigator/Program Director | Marianna Trakala |
| Cancer Sites | All Sites |
| Contracted Amount | $2,000,000 |
| Summary of Goals and Objectives |
Our proposed research focuses on understanding a common feature of many cancers: an abnormal number of chromosomes, called aneuploidy. This condition often leads to worse outcomes for cancer patients. While we know that certain features related with aneuploidy can sometimes activate the immune system, tumors often find ways to evade this immune response. Our goal is to uncover how the immune system detects aneuploid cells and how tumors manage to hide from this detection. Our goals are to: Identify which types of immune cells are involved in recognizing and eliminating aneuploid cells. Explore how aneuploidy changes the proteins on the surface of cells and how this affects the immune respo... |