Grant ID RR230081
Awarded On August 16, 2023
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Southern Methodist University
Principal Investigator/Program Director Annika Wylie
Cancer Sites All Sites
Contracted Amount $2,000,000
Summary of Goals and Objectives

The p53 gene is mutated in at least half of all human cancers but how this gene acts to suppress tumor formation is not well understood. Since p53 genes are broadly conserved, ancestral properties of these genes offer promising routes towards understanding functions that become deranged in human diseases. Using the Drosophila and zebrafish model systems, I discovered that p53 restricts transposons, and showed how p53 loss leads to an eruption of these mobile elements in mouse and human cancers (Wylie et al., Genes & Dev, 2016). Building on these observations, I showed that certain p53 isoforms act as constitutive repressors, operating continuously in unstressed cells through the same canonic...

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