Grant ID RR230029
Awarded On May 17, 2023
Title Recruitment of Established Investigators
Program CPRIT Scholar
Award Mechanism Recruitment of Established Investigators
Institution/Organization Rice University
Principal Investigator/Program Director Michael King
Cancer Sites Colorectal, Prostate
Contracted Amount $6,000,000
Summary of Goals and Objectives

The King Laboratory aims to leverage our expertise in cell mechanobiology, biotransport phenomena, and targeted drug delivery to reveal new insights into the physical and molecular mechanisms of metastatic cancer and translate these concepts to the clinic. Goal1: Elucidate the Mechanobiology of Cancer Cell Aggregates at the Blood Interface. Mechanotransduction of cancer cells in solid tumors is an active area of research, yet far less has been done to understand the response of cancer cells to fluid forces in blood flow. We have demonstrated the synergistic effect of shear stress and TRAIL on cellular apoptosis of circulating tumor cells (CTCs), as well as the unique ability of cancer cells ...

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