Grant ID RR230018
Awarded On February 15, 2023
Title Recruitment of Established Investigators
Program CPRIT Scholar
Award Mechanism Recruitment of Established Investigators
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Rudi Fasan
Cancer Sites All Sites
Contracted Amount $6,000,000
Summary of Goals and Objectives

Natural products have represented a prominent source of cancer drugs and valuable chemical probes for investigating cancer-associated biological processes. The structural complexity of these molecules, however, constitute a major hurdle toward their expeditious synthesis and manipulation, as required for their development into probes and therapeutics. Building upon our pioneering contributions in the development of chemo-enzymatic strategies for late-stage functionalization and diversification of complex natural products, this project will generate large libraries of novel and unique natural-product-like compounds as a readily accessible source of small-molecule agents for both basic cancer ...

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