Grant ID RR220101
Awarded On August 17, 2022
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Siqi Liu
Cancer Sites Sarcoma, Skin
Contracted Amount $2,000,000
Summary of Goals and Objectives

Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, causing ~10,000 annual deaths in the US, similar to the mortality rate of commonly studied cancers such as melanoma, leukemia, lymphoma, and urothelial cancers. Despite its increasing prevalence in an aging population, however, much less is known about high-risk cSCC (i.e. locally advanced or metastatic at presentation). Current therapies for high-risk cSCC are limited by high toxicity and low therapeutic efficacy. Chronic wounds, repetitive injury and burns are major risk factors for high-risk cSCCs, suggesting an oncogenic process that co-opts an abnormal ...

Read More