Grant ID RR220072
Awarded On May 18, 2022
Title Recruitment of Rising Stars
Program CPRIT Scholar
Award Mechanism Recruitment of Rising Stars
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Chistine Lovly
Cancer Sites Lung and Bronchus
Contracted Amount $4,000,000
Summary of Goals and Objectives

Biomarker testing to inform treatment planning is the standard of care worldwide for patients with non-small cell lung cancer. However, most patients still do not experience long term survival, due to incomplete responses to initial therapy and acquired resistance. The goal of this proposal is to develop novel therapeutic strategies based on an understanding of the genomic, molecular, and cellular changes involved in treatment response/resistance. Our three objectives are integrated under the premise of discovering new paradigms for mechanism-based therapies, each addressing critical gaps where the current framework for precision medicine falls short. (1) While multiple distinct variants can...

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