Grant ID RR220068
Awarded On May 18, 2022
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Elizabeth Wasmuth
Cancer Sites Prostate
Contracted Amount $2,000,000
Summary of Goals and Objectives

The androgen receptor (AR) is the master transcription factor responsible for development and maintenance of the male phenotype. Hyperactive AR signaling caused by AR gene amplification or coactivator overexpression is a hallmark of metastatic prostate cancer, which remains a major health burden in South Texas. Drugs that inhibit AR by outcompeting its steroid ligands have been used since the 1940s; however, resistance to these therapeutics inevitably arises through rebounds in AR signaling or alternative pathways that render tumors AR-independent. Development of more effective therapies that target AR’s oncogenic function requires a robust in vitro system that faithfully recapitulates AR ac...

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