Grant ID RR220053
Awarded On February 16, 2022
Title Recruitment of Established Investigators
Program CPRIT Scholar
Award Mechanism Recruitment of Established Investigators
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Reuben Harris
Cancer Sites Breast, Head and Neck, Ovary
Contracted Amount $6,000,000
Summary of Goals and Objectives

APOBEC-mediated DNA deamination dominates the mutational landscape of many tumors including those of the bladder, breast, cervix, head/neck, lung, and ovary. We discovered the DNA deaminase activity of APOBEC family members, the pivotal role of APOBEC3B (A3B) in breast and other cancer types, and key aspects of underlying molecular mechanism. Our findings provide the foundation to elucidate the molecular, biochemical, and structural details of the APOBEC mutagenesis process in cancer, to uncover novel synthetic lethal interactions that may be developed into novel therapies for APOBEC-positive tumors, and leverage viral and chemical knowledge to develop potent APOBEC inhibitors as a complemen...

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