Grant ID RR220033
Awarded On May 18, 2022
Title Recruitment of Established Investigators
Program CPRIT Scholar
Award Mechanism Recruitment of Established Investigators
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Pavan Reddy
Cancer Sites Leukemia, Lymphoma, Myeloma
Contracted Amount $6,000,000
Summary of Goals and Objectives

The therapeutic potential of T-cell immunotherapy is limited by major immunotoxicities such as graft-versus-host disease (GVHD), immune checkpoint blocker (ICB) colitis and the loss of persistence, and exhaustion of transferred T cells. This proposal aims to address these problems. It blends hypothesis-driven studies that are informed by unbiased discovery-based explorations. Most advances in the field are focused on the sensor and effector arms of the problem, namely the immune cells. Herein we will take a distinct approach; focus on both immune target cells and on effector T cells. Thus, the goals of the proposal are two themes that tackle the two ends of the immunotherapy: the targets and...

Read More