Grant ID RR220016
Awarded On November 18, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas at Dallas
Principal Investigator/Program Director Filippo Romiti
Cancer Sites Breast, Lung and Bronchus, Stomach
Contracted Amount $2,000,000
Summary of Goals and Objectives

The principal aim of the proposed studies will be the bench-to-bedside development of polycyclic polyprenylated acylphloroglucinols (PPAPs) into a new class of anti-cancer drugs through comprehensive synthetic and biological investigations. We will develop a practical, efficient, and versatile strategy for enantioselective synthesis of significant quantities of PPAPs so that detailed biological and pharmacokinetic studies can be easily and reliably performed. Access to a library of PPAPs analogs and preparation of antibody-drug conjugates (ADCs) will facilitate the discovery of novel, highly potent, and uniquely selective anti-cancer drugs. Aim 1: Practical strategy for synthesis of PPAPs. T...

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