Grant ID RR210080
Awarded On August 18, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Texas A&M Engineering Experiment Station
Principal Investigator/Program Director Jason George
Cancer Sites Leukemia, Lymphoma
Contracted Amount $1,999,309
Summary of Goals and Objectives

Objective: The rationale for the proposed research is the need to better understand the extent to which cancer populations adopt active immune evasion strategies to evade T cell recognition in the setting of allogeneic CD8+ T cell immunotherapy. We currently lack a theoretical framework for cancer T cell evasion.

Therefore, the objective of this research is to develop a mathematical model to quantify the degree to which cancer populations employ adaptive, immune-specific evasion strategies, to apply this model to experimental data detailing cancer immune recognition and evasion, and to propose model-predicted, optimized hematopoietic stem cell transplant (HSCT) strategies in the setting of a...

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