Grant ID RR210079
Awarded On August 18, 2021
Title Recruitment of Rising Stars
Program CPRIT Scholar
Award Mechanism Recruitment of Rising Stars
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Tian Zhang
Cancer Sites Kidney and Renal Pelvis
Contracted Amount $4,000,000
Summary of Goals and Objectives

I am a clinical trialist and translational researcher leading clinical trials in genitourinary (GU) malignancies. The overall goal of my research is to develop novel therapies for patients with GU cancers. The largest trial that I currently lead is the phase 3 study of sequential combination immunotherapy-based treatment for renal cell carcinoma, “PD-inhibitor nivolumab and ipilimumab vs. VEGF TKI cabozantinib with ipilimumab-nivolumab in metastatic untreated renal cell cancer (PDIGREE).”

This trial studies sequencing approaches for optimal immunotherapy delivery to understand further mechanisms of immunotherapy resistance. Imp...

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