Grant ID RR210077
Awarded On August 18, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Edward Grow
Cancer Sites Sarcoma
Contracted Amount $2,000,000
Summary of Goals and Objectives

The objective of this proposal is to define the role of a p53-dependent non-canonical DNA damage response and how its reactivation of transposable elements (TE) can be leveraged to stimulate effective immunotherapy in cancer. The premise we will investigate is that combining epigenetic modulation with stimulation of the p53-DUX4 axis will allow for TE reactivation and potent sensitization of cancer cells to immunotherapy.

Although checkpoint-based immune-therapy has yielded impressive clinical results, most patients do not respond likely because they exhibit poor basal tumor immunity. A deeper understanding of how to leverage...

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