Grant ID RR210059
Awarded On August 18, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Javier Garcia-Bermudez
Cancer Sites Lung and Bronchus, Pancreas, Skin
Contracted Amount $2,000,000
Summary of Goals and Objectives

Goal 1. Define biological role of squalene accumulation in tumors


  1. Identify mechanism by which squalene accumulation protects cancer cells from oxidative cell death.
  2. Define relevance of squalene in growth of hypoxic pancreatic ductal adenocarcinomas and breast cancers.
  3. Test whether inhibiting squalene synthesis sensitizes hypoxic tumors to therapies that induce oxidative stress.

Goal 2. Identify new antioxidant pathways and define their roles in cancer progression


  1. Determine how synthesis of glycosaminoglycans protects cancer cells from lipid peroxidation and ferroptosis. 

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