Grant ID RR210050
Awarded On May 19, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Cassandra Callmann
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $2,000,000
Summary of Goals and Objectives

The goal of the proposed work is to develop a new strategy for targeting hepatocellular carcinoma (HCC) tumors with high specificity, as a means of simultaneously delivering immunotherapeutic cargo and reprogramming the tumor immune landscape.

Galectin-3 (Gal-3) is a carbohydrate-binding protein that is highly overexpressed by HCC tumors and is correlated with poor prognosis. Moreover, Gal-3 binds to the surface of T cells and suppresses their tumoricidal action in tumors, leading to tumor immune escape. Herein, carbohydrate-polymer conjugates (CPCs) that bind to Gal-3 with high affinity in the tumor microenvironment will be developed and synthesized to include immunotherapeutic moieties alo...

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