Grant ID RR210048
Awarded On May 19, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Courtney Schroeder
Cancer Sites All Sites
Contracted Amount $2,000,000
Summary of Goals and Objectives

Cytoskeletal proteins are conventionally thought to be conserved, yet evolutionary diversification in the form of gene-family expansions and accelerated amino-acid substitutions are unexpectedly found among actins and tubulins in mammals, including humans. Expression of divergent cytoskeletal proteins is restricted to the testis, but these genes are frequently mis-expressed in cancers. I identified six testis cytoskeletal proteins that appear to play prominent roles in cancer biology as: high expression is prognostic for low probability of survival; many of their encoding genes are mutated, amplified, or deleted in several c...

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