Grant ID RR210035
Awarded On May 19, 2021
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Chen Yao
Cancer Sites Kidney and Renal Pelvis
Contracted Amount $2,000,000
Summary of Goals and Objectives

T cells become dysfunctional during cancer, a state termed T cell exhaustion, which limits tumor control by the immune system. Immune checkpoint inhibitors (ICI) are designed to reinvigorate antitumor T cell immunity, but only a fraction of cancer patients respond to these drugs. A newly discovered subset of CD8 T cells, known as stem-like CD8 T cells, mediates ICI-induced antitumor T cell immunity in mice and positively correlates with the ICI-induced response in cancer patients. Thus, enhancing the stem-like CD8 T cell response represents a potential strategy for improving the ICI efficacy.

Renal cell carcinoma (RCC), a prevale...

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