Grant ID RR210023
Awarded On February 17, 2021
Title Recruitment of Established Investigators
Program CPRIT Scholar
Award Mechanism Recruitment of Established Investigators
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Alexander Mazin
Cancer Sites All Sites
Contracted Amount $6,000,000
Summary of Goals and Objectives

Homologous recombination (HR) is the principal pathway for the error-free repair of DNA double-strand breaks and for DNA replication fork maintenance. Mutations in BRCA1, BRCA2 and other HR genes are responsible for half of hereditary breast and ovarian cancers and increase the risk of prostate, pancreatic, and other cancers. Dysfunction in HR genes renders tumor cells addictive to alternative DNA repair pathways such that inactivation of these pathways induces synthetic lethality. Thus, development of inhibitors of PARP (PARPi) has revolutionized therapy of BRCA-deficient cancers. However, the majority of cancer patients treated with PARPi eventually develop resistance to these agents, stre...

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