Grant ID RR210016
Awarded On November 18, 2020
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jihan Osborne
Cancer Sites Kidney and Renal Pelvis, Lung and Bronchus
Contracted Amount $2,000,000
Summary of Goals and Objectives

Cancer stem cells (CSCs) contribute to intra-tumor heterogeneity by providing the tumor with cells that can differentiate and de-differentiate according to the stress of the environment. CSC utilize many of the same developmental pathways used by normal stem/progenitor cells during embryogenesis, including those for energy consumption, increased proliferation, overcoming hypoxic conditions, and inducing migration. The RNA binding protein, Lin28 and the microRNA, (miRNA) let-7 are part of an evolutionarily conserved developmental feedback loop that acts as a heterochronic regulator of developmental timing in metazoans from worms to m...

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