Grant ID RR200112
Awarded On August 19, 2020
Title Recruitment of Established Investigators
Program CPRIT Scholar
Award Mechanism Recruitment of Established Investigators
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director David Gius
Cancer Sites Breast, Gallbladder, Liver and Intrahepatic Bile Duct, Prostate
Contracted Amount $6,000,000
Summary of Goals and Objectives

Our work addresses a fundamental issue in oncology, namely, that age represents a strong cancer risk factor. We focus on the biology of the sirtuin (SIRT) gene family and have developed murine models connecting the organismal physiology of aging and metabolic bioenergetics to carcinogenesis and tumor cell resistance. Dysregulation of antioxidant and energy regulating enzymes leads to perturbations in metabolic homeostasis and the accumulation of oxidized metabolites and reactive oxygen species that adversely affect cellular metabolism.

My laboratory has focused on understanding cell and mitochondrial networks that help maintain metabolic homeostasis and that, when disrupted, trigger early ev...

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