Grant ID RR200089
Awarded On August 19, 2020
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Peng Zhao
Cancer Sites Colorectal, Gallbladder, Liver and Intrahepatic Bile Duct, Pancreas
Contracted Amount $2,000,000
Summary of Goals and Objectives

Overnutrition disrupts metabolic homeostasis to cause obesity and the metabolic syndrome. Epidemiological studies by the Centers for Disease Control and Prevention demonstrate the prevalence of obesity has increased from 30.5% to 42.4% from 1999-2000 through 2017-2018. Obesity and obesity-associated metabolic dysfunction are major risk factors for cancer development and progression in multiple organ sites, including liver, colorectal, pancreatic, and kidney. However, the underlying mechanism by which metabolic dysfunction promotes oncogenesis remains largely unknown.

Obesity and metabolic syndrome frequently result in hepatic steatosis and nonalcoholic steatohepatitis (NASH). NASH has become...

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