|Awarded On||August 19, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Monica Pillon|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
Dysregulated gene expression is a universal feature of cancer that drives malignant phenotypes and patient outcomes. A central determinant of gene expression is mRNA abundance, highlighting the delicate balance between mRNA synthesis and decay.
While extensive work has revealed mechanisms by which aberrations in mRNA synthesis drive cancer (ex. Myc transcription factors), comparatively little is understood about dysregulated RNA decay and its impact on gene expression and cancer pathogenesis. Ribonucleases are central players in all RNA decay processes. Large functional genomics studies have recently identified many of the 122 annotated human ribonucleases as selective cancer vulnerabilities...