| Grant ID | RR200065 |
| Awarded On | May 20, 2020 |
| Title | Recruitment of First-Time, Tenure-Track Faculty Members |
| Program | CPRIT Scholar |
| Award Mechanism | Recruitment of First-Time, Tenure-Track Faculty Members |
| Institution/Organization | Baylor College of Medicine |
| Principal Investigator/Program Director | Jason Lee |
| Cancer Sites | All Sites |
| Contracted Amount | $2,000,000 |
| Summary of Goals and Objectives |
The goal of my research is to understand how the endoplasmic reticulum (ER) and membrane-less mRNA-protein (RNP) granules contribute to metastasis and inflammation. There are 3 significant moments in the life of a cancer cell. One is initiation, which is when a cell deviates from normal functions and transforms into a tumor-forming cancer cell. The second is metastasis, which is when a cancer cell switches once more to escape the tumor and seed new tumors. Lastly, tumor cells can alter pathways to obtain drug resistance. I recently discovered that RNP granule disassembly is regulated by a novel interface between the ER and RNP granules. I am excited to study this interface in the context of ... |