Grant ID RR200065
Awarded On May 20, 2020
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Jason Lee
Cancer Sites All Sites
Contracted Amount $2,000,000
Summary of Goals and Objectives

The goal of my research is to understand how the endoplasmic reticulum (ER) and membrane-less mRNA-protein (RNP) granules contribute to metastasis and inflammation.

There are 3 significant moments in the life of a cancer cell. One is initiation, which is when a cell deviates from normal functions and transforms into a tumor-forming cancer cell. The second is metastasis, which is when a cancer cell switches once more to escape the tumor and seed new tumors. Lastly, tumor cells can alter pathways to obtain drug resistance.

I recently discovered that RNP granule disassembly is regulated by a novel interface between the ER and RNP granules. I am excited to study this interface in the context of ...

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