Grant ID RR200007
Awarded On November 20, 2019
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Benjamin Drapkin
Cancer Sites Lung and Bronchus
Contracted Amount $2,000,000
Summary of Goals and Objectives

Small cell lung cancer (SCLC) afflicts more than 30,000 patients per year and is rapidly fatal in 95% of cases, with median survival of less than one year. Although untreated SCLC is highly responsive to first-line chemotherapy, benefit is temporary and following relapse, resistance often extends to a broad spectrum of DNA damaging agents. Also, investigational therapies in clinical trials are often confounded by the same cross-resistance that hinders standard second-line agents.

Although important, cross-resistance is difficult to study experimentally, as it requires a model system that faithfully reproduces clinical out...

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