|Awarded On||August 21, 2019|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Anju Sreelatha|
|Cancer Sites||Cervix Uteri, Gallbladder, Liver and Intrahepatic Bile Duct, Melanoma|
|Summary of Goals and Objectives||
Selenium has been extensively studied as a chemoprotective agent for decades; however, its molecular mechanism and functional role remain enigmatic. This essential micronutrient is incorporated into proteins in the form of the 21st amino acid, selenocysteine. The resulting selenoproteins are present in all domains of life and have been shown to regulate redox homeostasis. The oxidoreductase function of several selenoproteins has been shown to contribute to the dual personality of selenoproteins in cancer prevention and promotion.
I identified an unexpected catalytic activity for Selenoprotein O (SelO), one of the 25 human se...