Grant ID RR190071
Awarded On August 21, 2019
Title Recruitment of First-Time, Tenure-Track Faculty Members
Program CPRIT Scholar
Award Mechanism Recruitment of First-Time, Tenure-Track Faculty Members
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Jian Zhou
Cancer Sites All Sites
Contracted Amount $2,000,000
Summary of Goals and Objectives

Cancer progression is driven by genetic mutations that in turn lead to dysregulation of gene expression. With current efforts in cancer genome sequencing, much knowledge has been gained towards understanding the roles played by protein-disrupting mutations in cancer; however, major challenges remain in understanding the consequences of mutations that potentially disrupt DNA regulatory sequences and in assessing their contributions to cancer. These challenges are thus a barrier to a comprehensive understanding of cancer genetics and to realizing the full promise of precision therapies.

To bridge the gap between our abilities to ident...

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