|Awarded On||May 15, 2019|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Principal Investigator/Program Director||Yang Gao|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
Genome replication and maintenance play fundamental roles in both tumorigenesis and cancer treatment. The overarching goals of my research are to investigate the molecular mechanisms of genome replication and maintenance processes, how they work under normal and stress conditions, how their abnormalities lead to mutations, genome rearrangements and cancer, and how they selectively protect cancer genome integrity during cancer treatment.
In the immediate future, my laboratory will focus on pathways within mitochondria, which employ distinct proteins for genome replication and maintenance and play important roles during cancer development and progression. A deep understanding of mitochondria g...