The University of Texas Health Science Center at Houston (UTHealth) is one of the major institutes within the University of Texas System and part of the Texas Medical Center (TMC). UTHealth McGovern Medical School is the seventh-largest medical school in the United States - it currently has ~1500 faculty in 24 academic departments as well as 39 research centers or institutes in specific areas. For FY2023, total research awards for UTHealth exceeded $400 million. Among all the programs at UTHealth, cancer research has expanded rapidly in all the clinical, basic, preventive, and translational research areas. UTHealth has successfully recruited 11 CPRIT scholars since 2010. In addition, several...

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The University of Texas Health Science Center at Houston (UTHealth) is one of the major institutes within the University of Texas System and part of the Texas Medical Center (TMC). UTHealth McGovern Medical School is the seventh-largest medical school in the United States - it currently has ~1500 faculty in 24 academic departments as well as 39 research centers or institutes in specific areas. For FY2023, total research awards for UTHealth exceeded $400 million. Among all the programs at UTHealth, cancer research has expanded rapidly in all the clinical, basic, preventive, and translational research areas. UTHealth has successfully recruited 11 CPRIT scholars since 2010. In addition, several initiatives or programs are recently funded or proposed, including the Cancer Research Center of Excellence and the Office for Cancer Genomic Medicine. Among all these programs, cancer genomics is an essential component. Accordingly, UTHealth Cancer Genomics Core (CGC) was established in 2018 with the CPRIT initial funding (RP180734). The CGC has provided high-quality services to over 164 investigators across 18 academic institutes for their sequencing and genomics projects. In this renewal proposal, we will substantially expand our sequencing facilities by providing the state-of-the-art sequencing platforms including long-read sequencing, single cell omics, and spatial transcriptomics, enhance our customized project design and advanced bioinformatics services, expand our cancer genomics services to thousands of clinical samples through partnership with clinical departments and UTHealth affiliated hospitals, and finally offer our cancer genomics services to other Texas institutes. We anticipate the maximum impact on promoting cancer research and translational science in Texas through adopting the frontier genome technologies.

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