Grant ID RP240380
Awarded On February 21, 2024
Title Clonal hematopoiesis for improving lung cancer risk assessment
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Chao Cheng
Cancer Sites Lung and Bronchus
Contracted Amount $1,040,316
Lay Summary

Lung cancer is the most common cancer with a poor prognosis due to the fact that most patients are diagnosed at advanced stages. To reduce lung cancer mortality by early diagnosis, low-dose spiral computed tomography (LDCT) scans have been recommended for people who are 55 to 74 years old and currently smoke or have quit in the past 15 years. The current guideline for screening is limited by the accuracy of lung cancer risk assessment models. To further improve the guideline, it is necessary to consider additional lung cancer risk factors that can be easily tested. Recently, lung cancer-associated genetic variants have been added to the risk models but resulted in only modest improvement. Cl...

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