| Grant ID | RP240326 |
| Awarded On | February 21, 2024 |
| Title | Translation of gut commensal bacteria peptidoglycan remodeling pathway for chimeric antigen receptor T-cell therapy |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | The University of Texas M.D. Anderson Cancer Center |
| Principal Investigator/Program Director | Neeraj Saini |
| Cancer Sites | Lymphoma |
| Contracted Amount | $1,050,000 |
| Lay Summary |
Our bodies are home to different types of bacteria that live with us in harmony, called commensal microbiota. These bacteria can directly affect the success of immune-based cancer treatments like CART therapy. However, we still have limited knowledge about how specific bacteria impact the results of these therapies. By gaining a deeper understanding, we can develop new treatments and improve patient survival rates. In this proposal, we will carefully analyze our initial data, which has shown a connection between certain species of Enterococcus bacteria and the outcomes of CAR-T therapy. We will identify and confirm the protective factors associated with these bacteria tha... |