Grant ID RP240291
Awarded On February 21, 2024
Title Targeting MYCN disruption of the molecular clock and tumor metabolism in neuroblastoma oncogenesis.
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Eveline Barbieri
Cancer Sites Childhood and Adolescent
Contracted Amount $1,050,000
Lay Summary

Neuroblastoma is a very aggressive pediatric cancer, which accounts for 15% of all pediatric cancer deaths and has an overall survival of less than 45%. Current front-line therapies have reached maximum tolerated toxicity, and novel approaches are desperately needed. Importantly, patients with a specific genetic aberration, the amplification of the oncogene MYCN, relapse much earlier and develop resistance to current therapy modalities. Once relapsed, the overall survival for these patients is less than 20%. Cell metabolism, or the way in which cells take up and process nutrients such as sugars, amino acids, and lipids, is a key aspect of tumor cell biology. Cancer cells adopt distinct meta...

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