Grant ID RP240263
Awarded On February 21, 2024
Title Identifying the Biological Determinants of Aggressive Meningioma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Akash Patel
Cancer Sites Brain and Other Nervous System
Contracted Amount $1,049,370
Lay Summary

Meningioma is the most common primary brain tumor1,2. They occur more often in women and African Americans, each an underrepresented group in clinical trials. The current histopathological grading criteria3 fails to reliably predict the 20% of aggressive meningiomas3,4. To address this problem, we were the first group to use a multiplatform approach uncoupled from WHO criteria to identify three molecular groups (MenG A, B, and C) that better predict the risk of recurrence than the WHO system12. These groups can be identified using RNA sequencing, DNA methylation, or copy number analysis13. Over the past year, several independent groups have confirmed the validity of our three molecular group...

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