Grant ID RP240259
Awarded On February 21, 2024
Title Targeting Cancer-associated Lactobacillus iners to improve response to cancer therapy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Lauren Colbert
Cancer Sites Cervix Uteri, Vagina, Vulva
Contracted Amount $1,049,427*

*Pending contract negotiation

Lay Summary

Increasing evidence show that tumors have distinct microbial compositions (microbiome) compared to normal tissues, and that these microbiomes are strongly associated with cancer outcomes and treatment responses. In this project, we propose 1) to define and characterize the mechanisms by which certain subspecies of microbes associated with cervical cancers can affect tumor metabolism, cause cancer cell genetic modifications, and affect cancer treatment response, and 2) to design therapeutic approaches for elimination of these microbes that will use cancer-associated microbes' susceptibilities while preserving the presence of healthy bacterial subspecies. The future clinical testing of microbe-...

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