Grant ID RP240237
Awarded On February 21, 2024
Title The Role of EWSR1-FLI1-CENP-A Signaling in Chemoresistance in Ewing Sarcoma
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Katsumi Kitagawa
Cancer Sites Childhood and Adolescent, Sarcoma
Contracted Amount $1,400,000
Lay Summary

Ewing sarcoma (EwS) is a pediatric bone cancer, which is characterized by the expression of chimeric fusion protein EWSR1-FLI1. Metastatic or relapsed EwS responds poorly to treatment. Thus, new therapies are needed. A potential target for therapy is chromosome instability (CIN) in EwS cells. These cells display frequent chromosome gains or losses due to CIN. How CIN occurs in EwS is unknown. CENP-A is an essential component of the centromere, the chromosome locus that mediates chromosome segregation. Neocentromeres (newly created centromeres at non-centromeric regions) or dysfunctional centromeres promote CIN. Our goal is to learn how centromere dysfunction leads to CIN in EwS, and our hypo...

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