Grant ID RP240233
Awarded On February 21, 2024
Title Towards non-operative management of early stage ER-positive breast cancer
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Clinical Translation
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Asal Rahimi
Cancer Sites Breast
Contracted Amount $1,999,963
Lay Summary

Surgery is the cornerstone of treatment in patients with localized breast cancer. However, non-surgical treatments have the potential to reduce overall treatment-related toxicity and improve breast preservation while achieving comparable disease control. Stereotactic ablative radiation therapy (SABR) is an advanced treatment modality that achieves cancer controls rates >90% with minimum toxicity. Here, we propose a clinical trial where early stage Estrogen Receptor-positive breast cancer patients undergo preoperative SABR, evaluation of lymph node involvement with cancer via a non-surgical approach called microbubble contrast-enhanced ultrasound and evaluation of response to SABR using...

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