Grant ID RP240225
Awarded On February 21, 2024
Title PARP16-mediated Ribosome MARylation and Translation Control in Ovarian Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director W. Lee Kraus
Cancer Sites Brain and Other Nervous System, Ovary
Contracted Amount $1,049,743*

*Pending contract negotiation

Lay Summary

The transfer of information encoded by genes in the genome to messenger RNAs (mRNAs), which are translated into proteins that control specific cellular processes, in a fundamental process in biology. Cancer cells exert exceptional control over this process and dysregulate it as needed to gain a selective growth advantage versus normal cells. One mechanism that cancers use to control the translation of mRNAs into proteins is to add chemical groups on specific amino acids in proteins that comprise the cellular translation machinery. One such modification is called ADP-ribosylation (ADPRylation). We found that cancer cells increase ADPRylation of the translation machinery by increasing the ...

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