Grant ID RP240214
Awarded On February 21, 2024
Title Immunoprevention of Breast Cancer Brain Metastasis by Special Dendritic Cell-derived Extracellular Vesicles
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Dihua Yu
Cancer Sites Breast
Contracted Amount $1,050,000
Lay Summary

About 10-15% of breast cancer (BC) patients have their cancers spread to the brain (brain metastasis, or BrM) at late-stage of diseases. Particularly, one third of patients with HER2 gene overexpression (HER2+) or triple-negative BCs will develop BrM. Sadly, there are currently no effective treatments for BC BrM, resulting in a median survival time of only 7.2 months and extremely poor quality of life. If we can prevent BrM development, BC patients will have significantly longer survival and better quality of life. Since BrM usually develop much later, we reason that after patients are diagnosed with HER2+ or triple-negative BC, the long latent time is an opportunity to prevent or intervene...

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