Grant ID RP240183
Awarded On February 21, 2024
Title Restoring TREM2-Depedent Efferocytosis to Inhibit Obesity-Induced Liver Inflammation and Cancer Development
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Shuang Liang
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $1,049,997*

*Pending contract negotiation

Lay Summary

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. With a steady increase of obesity epidemic in the United States, the incidence of obesity-associated HCC has skyrocketed. Obesity-induced HCC is the terminal manifestation of non-alcoholic fatty liver disease (NAFLD) - a spectrum of chronic liver diseases originating from benign fatty liver that can progress into nonalcoholic steatohepatitis (NASH) and eventually HCC. Obesity induces lipid buildup in hepatocyte, resulting in cell death and subsequent release of danger molecules to ignite inflammation. Although previous studies have demonstrated that chronic liver inflammation is a "stage-setting" st...

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