Grant ID RP240127
Awarded On February 21, 2024
Title Transposon Restriction, Tumor Suppression and p53
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director John M Abrams
Cancer Sites All Sites
Contracted Amount $1,039,356
Lay Summary

The p53 gene is mutated in most human cancers. Collectively, these alterations represent the most common genetic change shared across the spectrum of tumors seen in patients. p53 belongs to a class of "tumor suppressor" genes that restrict tissue growth, but we do not have a definitive molecular explanation for how this gene prevents cancers. To better understand actions of p53 that, when disabled, permit cancer formation we built sophisticated platforms in genetic model systems. Leveraging insights from these, we discovered that p53 normally restrains a class of mobile elements called retrotransposons. Unlike most genetic material, these otherwise silent elements can rapidly amplify and mo...

Read More