Grant ID RP240125
Awarded On February 21, 2024
Title Immune-Related Determinants of HPV-Associated Oropharyngeal Cancer Outcomes
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Guojun Li
Cancer Sites Head and Neck
Contracted Amount $1,049,726
Lay Summary

Squamous cell carcinoma of the oropharynx (SCCOP) caused by human papillomavirus (HPV) accounts for more than half of all cases of head and neck cancers. While survival of HPV-associated SCCOP is better than SCCOP caused by tobacco, a considerable number of patients still do poorly. Most patients are treated with intensive, multi-modality therapy approaches incurring long-term toxicities. Identification of biomarkers and development of risk stratification models will allow individualized treatment strategies to minimize overtreatment and associated adverse effects. Tumor HPV status and presence of antibodies to HPV oncoproteins predict both risk and prognosis of SCCOP. Genome-wide associatio...

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