Grant ID RP240095
Awarded On February 21, 2024
Title Targeting chitinase-3-like-1 as a novel therapy for hepatocellular carcinoma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director Cynthia Ju
Cancer Sites Gallbladder, Liver and Intrahepatic Bile Duct
Contracted Amount $1,049,388
Lay Summary

Liver cancer is an aggressive cancer with poor prognosis, and it is now the 6th-leading cause of cancer-related death in the United States. Texas has the highest liver cancer incidence rate of all US states. Currently, treatment options for liver cancer are limited and not effective in prolonging cancer-free survival. Chitinase-3-like-1 (CHI3L1) is a glycoprotein released during tissue inflammation and remodeling. Serum levels of CHI3L1 is elevated in HCC patients and higher levels correlate with a poor prognosis. The goals of the proposed work are to understand the role of CHI3L1 in HCC development and to determine its potential as a therapeutic target. Our preliminary studies provide the f...

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