Grant ID RP240072
Awarded On February 21, 2024
Title Dissection of CAMKK2's Tumor Cell-intrinsic and -extrinsic Roles in Prostate Cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Daniel Frigo
Cancer Sites Prostate
Contracted Amount $1,050,000
Lay Summary

There is currently no cure for castration-resistant prostate cancer (CRPC). Further, standard of care treatments such as hormone therapy have associated comorbidities. Thus, mechanistically new treatment strategies are needed. We previously demonstrated an important role for Ca2+/calmodulin-dependent protein kinase kinase 2 (CAMKK2) in prostate cancer progression. But new data indicate that our previous understanding of how CAMKK2 promotes prostate cancer was incomplete. The goal of this proposal is to delineate emerging cancer cell-intrinsic and -extrinsic roles for CAMKK2 in advanced prostate cancer. We anticipate that systemic CAMKK2 inhibition may also sensitize tumors to other treatment...

Read More