Grant ID RP240068
Awarded On February 21, 2024
Title Understanding the Mechanism of Linker Histone Mutations in Malignancy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at San Antonio
Principal Investigator/Program Director Alexey Soshnev
Cancer Sites Lymphoma
Contracted Amount $997,770
Lay Summary

Genetic information is packaged and interpreted by cellular machinery within the context of chromatin, a complex of nucleic acids and regulatory proteins. Histone proteins are major constituents of chromatin. Over a third of patients diagnosed with B-cell lymphomas carry tumor-specific missense mutations in genes encoding one specific subtype of histone proteins, termed linker histone H1. Our recent results show that linker histones act as tumor suppressors in B-cells, wherein H1 loss drives pre-neoplastic expansion during germinal center reaction and accelerates lymphomagenesis in H1 dose-dependent manner. However, detailed mechanism of how H1 mutations lead to malignancy remains unclear. ...

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