Grant ID RP240061
Awarded On February 21, 2024
Title Deciphering Iron Redox Cycles in Ferroptosis-based Cancer Therapy
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Yi Lu
Cancer Sites All Sites
Contracted Amount $1,044,608*

*Pending contract negotiation

Lay Summary

The overall goal of this proposal is to decipher iron redox cycles in ferroptosis-based cancer therapy. While many cancer therapies are designed to induce apoptosis, a type of cell death, it is known that cell death resistance, to apoptosis in particular, is a predominant hallmark of cancer. Therefore, many drugs are ineffective, in part due to the genetic alterations of apoptotic pathways in cancers, leading to therapy resistance and tumor recurrence. Currently, clinical trials are underway for potential drug candidates that target a different cell death pathway involving iron, known as ferroptosis. However, despite a promising decade of research in this area, few ferroptosis-based cancer d...

Read More