Grant ID RP240035
Awarded On February 21, 2024
Title Harnessing the metabolic dependencies of mitochondrial NADK2 as a therapeutic strategy for lung cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Gerta Hoxhaj
Cancer Sites Lung and Bronchus
Contracted Amount $1,050,000*

*Pending contract negotiation

Lay Summary

Lung cancer is the leading cause of cancer-associated death, with many people succumbing to the disease within a year of diagnosis. This highlights the urgent need to find new ways to target and treat lung cancer. Our laboratory studies an important metabolic enzyme called NADK2, which is frequently found to be amplified in lung cancer. However, we still don't fully understand why lung cancer cells have more NADK2 or what role it plays in their growth. We made an interesting discovery that when we delete NADK2 from lung cancer cells, they become unable to produce a specific building block called proline, which they need to grow. Cells in our bodies can make proline on their own, so they do...

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