Grant ID RP230454
Awarded On August 16, 2023
Title Role of transcription factor UBTF in pancreatic cancer
Program Academic Research
Award Mechanism TREC: Pilot Study Award
Institution/Organization The University of Texas Rio Grande Valley
Principal Investigator/Program Director Bilal Hafeez
Cancer Sites Pancreas
Contracted Amount $200,000*

*Pending contract negotiation

Lay Summary

Pancreatic cancer (PanCa) is a significant problem, and its treatment is a major challenge in front of onco-physicians. It shows only marginal survival benefits of 6 months with the available therapeutics. According to the American Cancer Society, PanCa is the third leading cause of cancer-related deaths in the United States. Thus, understanding the biology of PanCa is urgently required. Aberrant ribosome biogenesis is the hallmark of many cancers and has been associated with poor prognosis. Cancer cells show a significantly high demand for protein synthesis and to meet this demand they modify ribosomal machinery to produce onco-ribosomes. Through this project, we for the first time will inv...

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