Grant ID RP230360
Awarded On February 15, 2023
Title Rational design, synthesis and biological evaluation of simplified taccalonolide analogs for the treatment of cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at San Antonio
Principal Investigator/Program Director Douglas Frantz
Cancer Sites All Sites
Contracted Amount $1,049,128
Lay Summary

Naturally occurring compounds have historically provided a rich source of successful drug treatments for cancer. In fact, several of Nature's chemical harvests have been directly developed into life-saving chemotherapies without chemical modification such as paclitaxel that is recognized on the World Health Organization's (WHO) list of essential medicines. However, the direct preclinical development of most natural products, even those with promising anti-cancer activities, remains a formidable challenge due to significant hurdles that impede the drug discovery process. Most significant of these hurdles is the lack of early drug supplies due to low natural abundance or complex chemical struc...

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