Grant ID RP230334
Awarded On February 15, 2023
Title Elucidating the mutagenesis mechanism of BRAF in melanoma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Seongmin Lee
Cancer Sites Skin
Contracted Amount $1,050,000
Lay Summary

The protein kinase BRAF activates MAP kinase signaling pathways that regulate cell proliferation. The oncogenic BRAF gene is mutated up to 70% of melanoma, the deadliest form of skin cancer. Interestingly, BRAF mutations predominantly occur at codon 600 (GTG) and are T-to-A transversions, leading to BRAF V600E mutations. While solar ultraviolet (UV) irradiation is the prime suspect for melanoma, the identity of DNA lesion responsible for the dominant BRAF mutations is unknown, limiting our understanding of melanoma-genesis mechanisms. This knowledge gap prompted us to search for DNA lesion driving the BRAF V600E mutagenesis. To gain mechanistic insights into the solar rays-induced BRAF muta...

Read More