Grant ID RP230285
Awarded On February 15, 2023
Title Harnessing Endoplasmic Reticulum Stress to Overcome Resistance to Immunotherapy in Immune-cold Breast Cancer
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Clinical Translation
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Xi Chen
Cancer Sites Breast
Contracted Amount $2,000,000
Lay Summary

One of the reasons why cancers arise or recur is their ability to evade the immune surveillance. Breakthrough discoveries over the past 3 decades revealed immune checkpoints molecules, such as PD-1, as key mechanism suppressing tumor-killing T cell function and thus enabling cancer evasion from immune surveillance. Immune checkpoint blockade therapy (ICBT), such as PD-1 inhibitor pembrolizumab, can fully awaken the dysfunctional T cells inside the tumors to destroy the constantly changing cancer cells. However, majority of triple-negative breast cancers (TNBC), the most aggressive form of breast cancer, have little or no T cells inside the tumors, a term called immune-cold. These patients ca...

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