|Awarded On||February 15, 2023|
|Title||Enhancing Immune Responses in Pancreatic Cancer by Stromal Inhibition of HIF2|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Cullen Taniguchi|
Pancreatic cancer is an almost universally deadly disease that has few effective treatments. Immunotherapy has been hailed as a modern cancer breakthrough since it can use a patient's own immune system to kill cancers anywhere in the body. Unfortunately, pancreatic cancer does not appear to have any measurable response to any known immunotherapy. One way that pancreatic cancer evades the immune system is through the biology of low oxygen, or hypoxia. As pancreatic cancer grows, it develops thick scar tissue that cuts off the blood supply to the tumor, making it hypoxic. Specialized cells called cancer-associated fibroblasts grow in this hypoxic scar and produce substances that allow the c...